This podcast presents content included in the updated and expanded Global Guidelines for the Nutritional Care of Preterm Infants -2nd Edition, published in 2021. Faculty authors share the latest data and key practice tips from their respective chapters, while highlighting continued research opportunities to advance nutritional care of preterm infants. Topics include preterm nutrition as it affects the brain, strategies to prevent growth faltering, critical periods for nutrition and long-term outcomes, the role of nutrition in neonatal lung function, and energy requirements for preterm infants.