A practical and evidence-based podcast on how to think about, diagnose, and treat substance use disorders in the Emergency Department and Acute Care. Why? One American dies every 6 minutes from a drug overdose, and one American dies every 5 minutes from excessive alcohol use. As many as 64% of adult Emergency Department (ED) patients meet criteria for problematic substance use. Patients with untreated substance use are 81% more likely to require admission when they come to the ED. We need to learn more and do better in treating substance use in the acute care setting.